How do modular RNA-binding proteins engage with mRNA networks?

Together with an interdisciplinary team, Nina has discovered how modular RNA-binding protein (RBPs) fine-tune mRNA regulation to support cell growth. By studying the mRNA transporter Rrm4 in Ustilago maydis, we found that its multiple RNA-binding domains (RBDs) work together in a precise way—some guide RNA interactions, while others determine function. This research reveals how RBPs help regulate key processes like energy production, cell shape, and stability. 

Read the preprint here. Congrats!

Exciting Publication by Senthil and Team!

Congratulations to Senthil and coworkers on their latest publication in PNAS: "Deciphering the RNA-binding protein network during endosomal mRNA transport." This groundbreaking study uncovers the structural mechanisms behind mRNA attachment during microtubule-dependent endosomal transport, with insights into the MLLE domain's role in RNA-protein interactions.

This work not only advances our understanding of polar growth in Ustilago maydis but also highlights parallels in human MLLE domains!

Read the full article here. Fantastic work, team!