We are hiring!

Florian has secured funding from the Boehringer Ingelheim foundation to study how microorganisms interact at the molecular level. Press release (in German)

Fungi rely on membrane receptors - especially GPCRs - to detect environmental and host-derived signals and convert them into cellular responses. While these systems are well understood in humans, their function in fungi is still largely unclear.

The project aims to uncover how fungal GPCRs work during host recognition and infection, with the long-term goal of identifying new strategies to control pathogenic microorganisms.

If you have a background in structural biology, biochemistry, membrane proteins, or GPCR research and are excited about uncovering how fungi communicate at the molecular level, we would love to hear from you. 

Apply here

On the frontpage!

How do RNA-binding proteins distinguish functional targets from the vast pool of cellular RNAs?

We’re excited to share our latest publication in Nucleic Acids Research (featured as breakthrough article), where we dissect how modular RNA-binding domains shape transcriptome-wide interactions. Focusing on the endosomal mRNA transporter Rrm4 in Ustilago maydis, we used a comparative iCLIP2 approach to resolve the contributions of its three RNA recognition motifs (RRMs) at unprecedented resolution.

Our results reveal a surprising division of labor: while the third RRM dominates global RNA binding, it is largely dispensable for function. In contrast, the essential regulatory interactions depend on a coordinated interplay between RRM1 and RRM2. By integrating RNA-binding and transcriptomic data, we show that these sites act as regulatory elements controlling mRNA abundance, thereby linking endosomal transport to mRNA stability.

This work uncovers how modular RNA-binding defines distinct RNA regulons governing mitochondrial activity, polarity, and cell wall remodeling—key processes underlying polar growth—and provides a broader framework for understanding how RBPs encode functional specificity within complex RNA networks.

Read the article here 

Vesicles as mRNA Couriers in the Cell

In a recent EMBO Reports article, Melissa and colleagues highlight vesicle-coupled mRNA transport as a key mechanism of intracellular communication. They describe how mRNAs associate with membrane-bound organelles and are locally translated, enabling precise spatial control of gene expression. This emerging concept reshapes our understanding of how organelles coordinate their functions to maintain cellular homeostasis.

Read more here.

How does a fungal pathogen know it's inside the host?

We’re excited to share our latest findings on how the maize pathogen Ustilago maydis senses when it has entered its plant host. In this study, we discovered a new GPCR-based system that links host protease activity to fungal signaling, allowing the pathogen to recognize the host environment and trigger infection-related responses. This work, led by Gabriel and Philip, uncovers the Gpe1–Pit2 system as a key example of how fungi translate host-derived cues into developmental decisions during infection.

Read the preprint here